We report a perchloric acid-catalyzed heteroannulation for the synthesis of spirocyclobutanes using vinyloxyphenylbicyclobutanes with water. This metal-free reaction yields high product outputs and is consistent with the formation of a cyclobutene intermediate originating from an isomerization of a bicyclobutane.
M. Takatsuki, H. Aoyama, M. Arisawa and M. Sako, Org. Biomol. Chem., 2024, 22, 4727 DOI: 10.1039/D4OB00451E
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