Issue 21, 2024

Photocatalytic C2-trifluoroethylation and perfluoroalkylation of 3-substituted indoles using fluoroalkyl halides

Abstract

A photocatalytic reactivity platform for the C2-trifluoroethylation and perfluoroalkylation of 3-substituted indoles has been developed. A range of fluoroalkyl halides have been employed as radical precursors under mild, transition-metal-free conditions to access new (per)fluorinated chemical space featuring the indole substructure. This general protocol is also applicable to indole-containing peptides.

Graphical abstract: Photocatalytic C2-trifluoroethylation and perfluoroalkylation of 3-substituted indoles using fluoroalkyl halides

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2024
Accepted
01 May 2024
First published
01 May 2024

Org. Biomol. Chem., 2024,22, 4278-4282

Photocatalytic C2-trifluoroethylation and perfluoroalkylation of 3-substituted indoles using fluoroalkyl halides

S. Arora, T. Singh and A. Singh, Org. Biomol. Chem., 2024, 22, 4278 DOI: 10.1039/D4OB00392F

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