Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Abstract

An efficient and practical method for the synthesis of 3-alkenylquinoxalinones containing the SCF₃ group has been readily developed through a three-component radical cascade reaction involving quinoxalinones, alkynes and AgSCF₃. The reaction was found to be compatible with a variety of substrates and exhibited a high functional group tolerance and complete E-selectivity. The preliminary study suggests the involvement of a SCF₃ radical in the transformation.