Issue 18, 2024

Recent developments in the enzymatic modifications of steroid scaffolds

Abstract

Steroids are an important family of bioactive compounds. Steroid drugs are renowned for their multifaceted pharmacological activities and are the second-largest category in the global pharmaceutical market. Recent developments in biocatalysis and biosynthesis have led to the increased use of enzymes to enhance the selectivity, efficiency, and sustainability for diverse modifications of steroids. This review discusses the advancements achieved over the past five years in the enzymatic modifications of steroid scaffolds, focusing on enzymatic hydroxylation, reduction, dehydrogenation, cascade reactions, and other modifications for future research on the synthesis of novel steroid compounds and related drugs, and new therapeutic possibilities.

Graphical abstract: Recent developments in the enzymatic modifications of steroid scaffolds

Article information

Article type
Review Article
Submitted
29 Feb 2024
Accepted
15 Apr 2024
First published
16 Apr 2024
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2024,22, 3559-3583

Recent developments in the enzymatic modifications of steroid scaffolds

H. Wang and I. Abe, Org. Biomol. Chem., 2024, 22, 3559 DOI: 10.1039/D4OB00327F

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