Ru–Mg promoted reductive cross-coupling of allyl bromides and alkenes to synthesize 1,7-octadienes with an all-carbon quaternary center

Abstract

A Ru-promoted reductive cross-coupling of allyl bromides and electron-deficient alkenes to provide terminal 1,7-octadienes with magnesium as a reductant is reported herein. This approach enables the facile construction of a series of complex terminal 1,7-octadienes with an all-carbon quaternary center under mild reaction conditions, and the synthetic utility of the current method has been demonstrated by a gram scale synthesis. Preliminary mechanism investigations suggested that a radical pathway might not be involved in this transformation.