Issue 7, 2024

Visible-light-induced synthesis of 2,4-disubstituted quinolines from o-vinylaryl isocyanides and oxime esters

Abstract

A visible-light-induced radical cyclization reaction of o-vinylaryl isocyanides and oxime esters to access various 2,4-disubstituted quinolines was disclosed. Oxime esters were employed as acyl radical precursors via the carbon–carbon bond cleavage. It provided an effective way for the synthesis of 2-acyl-4-arlysubstituted quinolines under mild conditions and exhibited good functional group tolerance and substrate applicability.

Graphical abstract: Visible-light-induced synthesis of 2,4-disubstituted quinolines from o-vinylaryl isocyanides and oxime esters

Supplementary files

Article information

Article type
Paper
Submitted
18 Dec 2023
Accepted
19 Jan 2024
First published
20 Jan 2024

Org. Biomol. Chem., 2024,22, 1458-1465

Visible-light-induced synthesis of 2,4-disubstituted quinolines from o-vinylaryl isocyanides and oxime esters

Y. Liu, C. Ding, J. Huang, Q. Zhou, B. Xiong, K. Tang and P. Huang, Org. Biomol. Chem., 2024, 22, 1458 DOI: 10.1039/D3OB02060F

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