Issue 1, 2024

Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben–Hoesch cyclization 2-step sequence

Abstract

Herein we report the efficient and selective two-step synthesis of various 3-silyl-2-amidoindenones from easily accessible ynamides. This sequence involves a regio- and stereo-selective silylcyanation followed by a Houben–Hoesch type cyclization. Thanks to post-transformations, various 3-substituted 2-amidoindenones could be obtained.

Graphical abstract: Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben–Hoesch cyclization 2-step sequence

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov 2023
Accepted
28 Nov 2023
First published
29 Nov 2023

Org. Biomol. Chem., 2024,22, 70-73

Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben–Hoesch cyclization 2-step sequence

P. Hansjacob, C. Schwoerer, F. R. Leroux and M. Donnard, Org. Biomol. Chem., 2024, 22, 70 DOI: 10.1039/D3OB01787G

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