Issue 8, 2024

Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Abstract

Access to the brain is restricted by the low permeability of the blood–brain barrier (BBB), greatly hampering modern drug delivery efforts. A promising approach to overcome this boundary is to utilize biomacromolecules (peptides, nucleic acids, carbohydrates) as targeting ligands on nanoscale delivery vehicles to shuttle cargo across the BBB. In this mini-review, we highlight the most recent approaches for crossing the BBB using synthetic nanoscale constructs decorated with members of these general classes of biomacromolecules to safely and selectively deliver therapeutic materials to the brain.

Graphical abstract: Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

Article information

Article type
Minireview
Submitted
01 Dec 2023
Accepted
18 Jan 2024
First published
20 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2024,16, 3969-3976

Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier

T. L. Odom, H. D. LeBroc and C. E. Callmann, Nanoscale, 2024, 16, 3969 DOI: 10.1039/D3NR06154J

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