Issue 9, 2024

An electrografted monolayer of polyaniline as a tuneable platform for a glucose biosensor

Abstract

Polyaniline (PANI), a nanostructured conducting polymer, has shown significant potential in optical and bioelectrochemical devices. However, its performance and stability on various substrates are hindered by weak adhesion to the surface. In this study, a strongly adherent polyaniline conducting polymer layer with a thickness of five nanometers was electrografted onto an initiating monolayer on gold and tin-doped indium oxide substrates. These electrografted monolayers consist of vertically oriented fully oxidized-protonated (pernigraniline salt) and deprotonated (pernigraniline base) forms of polyaniline. The monolayer exhibits pH-dependent colour changes and it is suitable for enzyme compatibility. In light of these findings, we have developed and characterized an electrochemical glucose biosensor based on the monolayer of polyaniline on a gold electrode. The biosensor utilizes glucose oxidase as the biorecognition element for the selective detection of glucose concentrations in real blood plasma samples.

Graphical abstract: An electrografted monolayer of polyaniline as a tuneable platform for a glucose biosensor

Supplementary files

Article information

Article type
Paper
Submitted
27 Jul 2023
Accepted
18 Jan 2024
First published
01 Feb 2024

Nanoscale, 2024,16, 4647-4655

An electrografted monolayer of polyaniline as a tuneable platform for a glucose biosensor

E. Ragauskaitė, S. Marčiukaitis, I. Radveikienė and G. Bagdžiūnas, Nanoscale, 2024, 16, 4647 DOI: 10.1039/D3NR03680D

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