Issue 2, 2025

Carbon nanospheres: an antimicrobial approach for methicillin-resistant Staphylococcus aureus (MRSA) infection in diabetic foot ulcer

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial strain that induces infections and exhibits resistance to most standard medications, complicating treatment efforts. MRSA infections pose a significant challenge, particularly for those with diabetic foot infections, frequently resulting in hospitalisation and, in some cases, amputation of the affected leg. To address this issue, we concentrated on synthesising carbon nanospheres (CNS) utilising a technique known as probe ultrasonication. These tiny particles exhibit biocompatibility and possess antimicrobial characteristics. Due to their small size and extensive surface area, CNS can penetrate the bacterial cell wall and carry medications more efficiently. We examined and analysed the CNS using several methodologies like XRD, Raman, FTIR, zeta potential, TEM and SEM to comprehend its structure and characteristics. We also examined their efficacy against MRSA bacteria at several dosages. The findings indicate that CNS may serve as an effective intervention for MRSA infections in diabetic foot ulcers, thereby decreasing the necessity for hospitalisation or amputations.

Graphical abstract: Carbon nanospheres: an antimicrobial approach for methicillin-resistant Staphylococcus aureus (MRSA) infection in diabetic foot ulcer

Article information

Article type
Paper
Submitted
25 Sep 2024
Accepted
24 Nov 2024
First published
26 Nov 2024

New J. Chem., 2025,49, 497-513

Carbon nanospheres: an antimicrobial approach for methicillin-resistant Staphylococcus aureus (MRSA) infection in diabetic foot ulcer

S. R. Sah, D. B. Samal and G. D. Venkatasubbu, New J. Chem., 2025, 49, 497 DOI: 10.1039/D4NJ04143G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements