Carbon nanospheres: an antimicrobial approach for methicillin-resistant Staphylococcus aureus (MRSA) infection in diabetic foot ulcer
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial strain that induces infections and exhibits resistance to most standard medications, complicating treatment efforts. MRSA infections pose a significant challenge, particularly for those with diabetic foot infections, frequently resulting in hospitalisation and, in some cases, amputation of the affected leg. To address this issue, we concentrated on synthesising carbon nanospheres (CNS) utilising a technique known as probe ultrasonication. These tiny particles exhibit biocompatibility and possess antimicrobial characteristics. Due to their small size and extensive surface area, CNS can penetrate the bacterial cell wall and carry medications more efficiently. We examined and analysed the CNS using several methodologies like XRD, Raman, FTIR, zeta potential, TEM and SEM to comprehend its structure and characteristics. We also examined their efficacy against MRSA bacteria at several dosages. The findings indicate that CNS may serve as an effective intervention for MRSA infections in diabetic foot ulcers, thereby decreasing the necessity for hospitalisation or amputations.