In vitro corrosion behavior and biocompatibility of biodegradable Mg–Mn–Zn alloy modified with a MOF/3D rGO/PCL three-layer coating

Abstract

Magnesium alloys are widely used for orthopedic implants due to their biocompatibility and biodegradability. However, their low corrosion resistance limits their application, particularly in physiological environments. The goal of this study is to examine how a three-layer coating, consisting of MOF/3D rGO/PCL, affects the corrosion resistance and in vitro biocompatibility of a biodegradable Mg–Mn–Zn alloy in a simulated body fluid (SBF). Corrosion behavior was evaluated using potentiodynamic polarization and electrochemical impedance spectroscopy. The results demonstrate a significant enhancement in the corrosion resistance of the modified alloy. Additionally, cell culture experiments were conducted to investigate the biocompatibility of the coatings. The data from the methylthiazole tetrazolium (MTT) and alkaline phosphatase (ALP) bioassays indicate a substantial improvement in the growth process of MC3T3-E1 osteoblastic cells and an increase in ALP activity in SBF. This confirms the non-toxicity and biocompatibility of the synthesized coating in the SBF solution. The findings of this study will be valuable for the development of biodegradable materials in biomedical applications.