Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator

Dehan Cao; Bin Chen; Yigong Xu; Zongyi Li; Tingfeng Sun; Sheng Hong; Tianen Zhu; Lei Chen; Ximeng Li; Longxiang Wang; Jiakai Liu; Yaqi Jin; Shuao Wang; Juan Diwu

doi:10.1039/D4NJ00986J

Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator†

Dehan Cao,‡^a Bin Chen,

‡^a Yigong Xu,

^a Zongyi Li,^a Tingfeng Sun,^a Sheng Hong,^a Tianen Zhu,^a Lei Chen,^a Ximeng Li,^a Longxiang Wang,^a Jiakai Liu,^a Yaqi Jin,^a Shuao Wang

^a and Juan Diwu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
E-mail: diwujuan@suda.edu.cn

Abstract

In conjunction with theoretical calculations, the in vitro and in vivo uranyl binding capabilities of a bidentate picolinate (Pic) ligand and its pentadentate derivative (H₂dpa) are investigated. The planar N₃O₂-donor configuration of H₂dpa matches the typical pentagonal-bipyramid coordination geometry of uranyl, demonstrating a remarkable removal preference for uranyl in the kidneys.

New Journal of Chemistry

Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator†

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Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator

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