Issue 4, 2024
From the journal:

New Journal of Chemistry

Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes†

Ziren Mao,a   Yiliang Zhou,a   Jingming Zhang,a   Chengkou Liu,a   Chang-Sheng Wang,a   Xiaobing Yang,b   Hong Qin,*a   Zheng Fang ORCID logo *a  and  Kai Guo ORCID logo ac  

* Corresponding authors

a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
E-mail: fzcpu@njtech.edu.cn

b China Biology and Medicine Department, Jiangsu Industrial Technology Research Institute, Nanjing 210031, P. R. China

c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

Abstract

An efficient strategy to construct α-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions.

Graphical abstract: Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

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Article information

DOI
https://doi.org/10.1039/D3NJ05081E
Article type
Paper
Submitted
03 Nov 2023
Accepted
30 Nov 2023
First published
02 Dec 2023

New J. Chem., 2024,48, 1735-1740

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Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

Z. Mao, Y. Zhou, J. Zhang, C. Liu, C. Wang, X. Yang, H. Qin, Z. Fang and K. Guo, New J. Chem., 2024, 48, 1735 DOI: 10.1039/D3NJ05081E

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