Issue 12, 2024

RSM optimization of Friedel–Crafts C-acylation of para-fluorophenol over the catalysis of phosphomolybdic acid encapsulated in MIL-53 (Fe) metal organic frameworks

Abstract

In this research, a heterogeneous acid catalyst was synthesized by room temperature encapsulation of phosphomolybdic acid (PMA) in the pores of the MIL-53 (Fe) metal organic framework (MOF) under ultrasonic conditions. Then the catalytic activity of PMA@MIL-53 (Fe) was investigated in Friedel–Crafts C-acylation of para-fluorophenol, and this procedure was optimized using response surface methodology based on central composite design (RSM-CCD). The impact of critical reaction parameters including reaction duration, catalyst dosage, and PMA amount in the catalyst was optimized, leading to the formation of the target product in excellent yield at a short reaction time.

Graphical abstract: RSM optimization of Friedel–Crafts C-acylation of para-fluorophenol over the catalysis of phosphomolybdic acid encapsulated in MIL-53 (Fe) metal organic frameworks

Article information

Article type
Paper
Submitted
17 Dec 2023
Accepted
10 Apr 2024
First published
06 May 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 3158-3168

RSM optimization of Friedel–Crafts C-acylation of para-fluorophenol over the catalysis of phosphomolybdic acid encapsulated in MIL-53 (Fe) metal organic frameworks

A. Nikseresht, R. Mehravar and M. Mohammadi, Nanoscale Adv., 2024, 6, 3158 DOI: 10.1039/D3NA01126G

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