Issue 1, 2024

Hollow metal–organic framework-based, stimulator of interferon genes pathway-activating nanovaccines for tumor immunotherapy

Abstract

Nanovaccines have emerged as promising agents for cancer therapy because of their ability to induce specific immune responses without off-target effects. However, inadequate cytotoxic T lymphocyte response and low antigen/adjuvant encapsulation remain major obstacles to vaccinating against cancer. Herein, we designed a stimulator of interferon genes (STING) pathway-activating nanovaccine based on hollow metal–organic frameworks (MOFs) for tumor treatment. The nanovaccine (OVA@HZIF-Mn) was constructed by encapsulating a model antigen ovalbumin (OVA) into zeolitic imidazolate framework-8, followed by etching with tannic acid and functionalizing with manganese ions. Studies have shown that the nanovaccine can effectively enhance antigen uptake, STING pathway activation and dendritic cell maturation, triggering a robust immune response to inhibit tumor growth. In addition, no infection or pathological signs were observed in mice organs after multiple administrations. This study combines a simple assembly approach and superior therapeutic effect, providing a promising strategy for engineering effective nanovaccines.

Graphical abstract: Hollow metal–organic framework-based, stimulator of interferon genes pathway-activating nanovaccines for tumor immunotherapy

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2023
Accepted
30 Nov 2023
First published
08 Dec 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 72-78

Hollow metal–organic framework-based, stimulator of interferon genes pathway-activating nanovaccines for tumor immunotherapy

Y. Zhao, R. Song, Z. Zhang, H. Hu, W. Ning, X. Duan, J. Jiao, X. Fu and G. Zhang, Nanoscale Adv., 2024, 6, 72 DOI: 10.1039/D3NA00867C

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