Issue 4, 2024
From the journal:

Materials Advances

3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model†

Zhongchao Zhao, ORCID logo ‡abc   Yi Xiang,‡a   Edward C. Koellhoffer,d   Sourabh Shukla,a   Steven Fiering,ef   Shaochen Chen*abgh  and  Nicole F. Steinmetz ORCID logo *abcdghij  

* Corresponding authors

a Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA
E-mail: chen168@ucsd.edu, nsteinmetz@ucsd.edu

b Center for Nano-ImmunoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

c Moores Cancer Center, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

d Department of Radiology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

e Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA

f Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA

g Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

h Institute for Materials Discovery and Design, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

i Center for Engineering in Cancer, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

j Shu and K.C. Chien and Peter Farrell Collaboratory, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

Abstract

Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to serve as depots for cancer slow-release immunotherapy. Sustained release of CPMV within the intraperitoneal space alleviates the need for repeated dosing and we demonstrated efficacy against ovarian cancer in a metastatic mouse model.

Graphical abstract: 3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model

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Article information

DOI
https://doi.org/10.1039/D3MA00899A
Article type
Communication
Submitted
24 Oct 2023
Accepted
22 Jan 2024
First published
01 Feb 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 1480-1486

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3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model

Z. Zhao, Y. Xiang, E. C. Koellhoffer, S. Shukla, S. Fiering, S. Chen and N. F. Steinmetz, Mater. Adv., 2024, 5, 1480 DOI: 10.1039/D3MA00899A

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