Issue 10, 2024

Microflow sensing and control using an in-channel birefringent biomembrane

Abstract

This study describes the function, optimization, and demonstration of a new class of passive, low-cost microfluidic flow meters based on birefringent chitosan biomembranes analyzed by polarized microscopy. We subjected the membrane to dynamic flow conditions while monitoring the real-time response of its optical properties. We obtained figures of merit, including the linear response operating range (0 to 65 μL min−1), minimum response time (250 ms), sensitivity (2.03% × 10−3 μL−1 min), and minimum sensor longevity (1 week). In addition, possible sources of interference were identified. Finally, we demonstrate the membrane as a low-cost flow rate measurement device for the close loop control of a commercial pressure-driven pump. Preliminary experiments using a basic PID controller with the membrane-based flow rate measurement device showed that stable control could be achieved and the system could reach steady-state behavior in less than 15 seconds. Analysis of fundamental limits to sensor response time indicate the potential for faster steady-state behaviour.

Graphical abstract: Microflow sensing and control using an in-channel birefringent biomembrane

Supplementary files

Article information

Article type
Paper
Submitted
14 Nov 2023
Accepted
25 Mar 2024
First published
19 Apr 2024
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2024,24, 2633-2643

Microflow sensing and control using an in-channel birefringent biomembrane

N. Jia, T. Deng, C. Larouche, T. Galstian, A. Bégin-Drolet and J. Greener, Lab Chip, 2024, 24, 2633 DOI: 10.1039/D3LC00985H

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