Issue 19, 2024

Electrochemically promoted selenocyclization for the synthesis of organoselenyl isoxazoles

Abstract

An electrochemically promoted protocol has been successfully developed for the synthesis of 4-organoselenyl isoxazoles via the oxidative selenocyclization of 2-alkyn-1-one O-methyloximes with diorganyl diselenides as selenation reagents. A wide range of titled compounds were obtained in over 80% yields without an additional catalyst or external oxidant. In comparison with existing methods, this newly developed protocol featured broader substrate scopes, higher selectivity and more atom economy.

Graphical abstract: Electrochemically promoted selenocyclization for the synthesis of organoselenyl isoxazoles

Supplementary files

Article information

Article type
Paper
Submitted
19 Jul 2024
Accepted
25 Aug 2024
First published
27 Aug 2024

Green Chem., 2024,26, 10240-10246

Electrochemically promoted selenocyclization for the synthesis of organoselenyl isoxazoles

N. Sun, Z. Qiao, J. Li, J. Gu, L. Jin and X. Hu, Green Chem., 2024, 26, 10240 DOI: 10.1039/D4GC03547J

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