Electrochemical direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines

Abstract

We have developed a straightforward electrochemical protocol for direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines with amides or pyrazoles. Unlike previously reported methods, this protocol does not require pre-prepared amidation reagents, thereby shortening the synthesis route and boosting atom economy. Various functional groups are tolerated, and the reaction proceeds at room temperature in only 2.5 h without assistance from chemical oxidants or catalysts.