Issue 9, 2024

The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

Abstract

This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model. Results show that maternal weight had a significant positive correlation with litter mortality in mice. A long-term HFD increased body weight and litter mortality with decreased expression of uterine cytochrome oxidase 4 (COX4), which was recovered by resveratrol in mice. Moreover, HFD decreased the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factors-1 (Nrf-1), and phosphorylated adenosine 5′-monophosphate (AMP)-activated protein kinase (p-AMPK) and increased the expression of phosphorylated extracellular regulated protein kinases (p-ERK) in the uterus. Resveratrol, a polyphenol that can directly bind to the ERK protein, suppressed the phosphorylation of ERK, increased the expression of p-AMPK, PGC-1α and Nrf-1, and decreased litter mortality in mice.

Graphical abstract: The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

Supplementary files

Article information

Article type
Paper
Submitted
08 Feb 2024
Accepted
16 Mar 2024
First published
26 Mar 2024

Food Funct., 2024,15, 4852-4861

The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

X. Yang, R. Hu, L. Yao, W. Zhang, M. Shi, J. Gong, X. Yuan, Y. Li, J. Yan, Y. Wang, Q. Zhang, Z. He, D. Hou, Z. Fan, H. Zhang, L. Chen, X. He, J. He and S. Wu, Food Funct., 2024, 15, 4852 DOI: 10.1039/D4FO00671B

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