Issue 5, 2024

Plasmonic-based Raman sensor for ultra-sensitive detection of pharmaceutical waste

Abstract

Pharmaceutical waste and contaminants pose a significant global concern for water and food safety. The detection of piperidine, a common residue in drug and supplement synthesis, is critical due to its toxic nature to both humans and animals. In this study, we develop a plasmonic-based detector for surface enhanced Raman scattering (SERS) measurements. The plasmonic device is composed of triangular cavities, milled in silver thin film, and protected by a 5 nm SiO2 layer. Due to the confined and enhanced electromagnetic field, remarkable sensitivity to piperidine with a concentration of 10−8 M in water is achieved. Despite the relatively small polarizability of piperidine, high sensitivity is observed even when using a low numerical aperture of 0.3, attributed to the directional scattering from our plasmonic device. Thus, it offers a cost-effective alternative to traditional high numerical aperture used in SERS, and the ability to use a portable Raman device for a cheaper and faster analysis.

Graphical abstract: Plasmonic-based Raman sensor for ultra-sensitive detection of pharmaceutical waste

Supplementary files

Article information

Article type
Paper
Submitted
13 Nov 2023
Accepted
08 Mar 2024
First published
11 Mar 2024
This article is Open Access
Creative Commons BY-NC license

Environ. Sci.: Nano, 2024,11, 2083-2090

Plasmonic-based Raman sensor for ultra-sensitive detection of pharmaceutical waste

M. Hamode, A. Krause, M. Shehadeh, B. Schmerling, T. Zar, I. Pinkas, D. Zitoun and A. Salomon, Environ. Sci.: Nano, 2024, 11, 2083 DOI: 10.1039/D3EN00821E

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