Issue 28, 2024

The effect of ionic versus covalent functionalization of polyoxometalate hybrid materials with coordinating subunits on their stability and interaction with DNA

Abstract

Inorganic–organic hybrid materials that combine both Polyoxometalates (POMs) and metal ion coordinating subunits (CSUs) represent promising multifunctional materials. Though their individual components are often biologically active, utilization of hybrid materials in bioassays significantly depends on the functionalization method and thus resulting stability of the system. Quite intriguingly, these aspects were very scarcely studied in hybrid materials based on the Wells–Dawson POM (WD POM) scaffold and remain unknown. We chose two model WD POM hybrid systems to establish how the functionalization mode (ionic vs. covalent) affects their stability in biological medium and interaction with nucleic acids. The synthetic scope and limitations of the covalent POM-terpyridine hybrids were demonstrated and compared with the ionic Complex-Decorated Surfactant Encapsulated-Clusters (CD-SECs) hybrids. The nature of POM and CSU binding can be utilized to modulate the stability of the hybrid and the extent of DNA binding. The above systems show potential to behave as model cargo-platforms for potential utilization in medicine and pharmacy.

Graphical abstract: The effect of ionic versus covalent functionalization of polyoxometalate hybrid materials with coordinating subunits on their stability and interaction with DNA

Supplementary files

Article information

Article type
Paper
Submitted
02 Apr 2024
Accepted
09 May 2024
First published
09 May 2024

Dalton Trans., 2024,53, 11678-11688

The effect of ionic versus covalent functionalization of polyoxometalate hybrid materials with coordinating subunits on their stability and interaction with DNA

D. Nowicka, D. Marcinkowski, N. Vadra, M. Szymańska, M. Kubicki, G. Consiglio, W. Drożdż, A. R. Stefankiewicz, V. Patroniak, M. Fik-Jaskółka and A. Gorczyński, Dalton Trans., 2024, 53, 11678 DOI: 10.1039/D4DT00965G

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