The effect of the DNA support on Pd/DNA catalyzed organic transformations

Abstract

Palladium-catalyzed organic transformations play a crucial role in organic synthesis, serving as vital tools for synthesizing significant classes of molecules and biologically active compounds. However, palladium, being a noble metal, has limited sources, posing sustainable challenges. DNA, known as the molecule of life, provides excellent opportunities for interaction with metals due to the nucleobases and phosphate groups present in its structure. DNA-supported palladium catalysts have demonstrated efficient catalytic activities across a diverse range of reactions, including cross-coupling, carbonylative cross-coupling, hydrogenation, oxidation, and imination reactions, for the synthesis of important classes of compounds such as acids, amides, biphenyls, alkynes, amines, and enaminones. The beneficial impact of DNA support on the reactivity and recyclability of palladium has been substantiated for sustainability issues.