Issue 12, 2024

Multimodal optoacoustic imaging: methods and contrast materials

Abstract

Optoacoustic (OA) imaging offers powerful capabilities for interrogating biological tissues with rich optical absorption contrast while maintaining high spatial resolution for deep tissue observations. The spectrally distinct absorption of visible and near-infrared photons by endogenous tissue chromophores facilitates extraction of diverse anatomic, functional, molecular, and metabolic information from living tissues across various scales, from organelles and cells to whole organs and organisms. The primarily blood-related contrast and limited penetration depth of OA imaging have fostered the development of multimodal approaches to fully exploit the unique advantages and complementarity of the method. We review the recent hybridization efforts, including multimodal combinations of OA with ultrasound, fluorescence, optical coherence tomography, Raman scattering microscopy and magnetic resonance imaging as well as ionizing methods, such as X-ray computed tomography, single-photon-emission computed tomography and positron emission tomography. Considering that most molecules absorb light across a broad range of the electromagnetic spectrum, the OA interrogations can be extended to a large number of exogenously administered small molecules, particulate agents, and genetically encoded labels. This unique property further makes contrast moieties used in other imaging modalities amenable for OA sensing.

Graphical abstract: Multimodal optoacoustic imaging: methods and contrast materials

Article information

Article type
Review Article
Submitted
19 Dec 2023
First published
13 May 2024
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2024,53, 6068-6099

Multimodal optoacoustic imaging: methods and contrast materials

Z. Chen, I. Gezginer, Q. Zhou, L. Tang, X. L. Deán-Ben and D. Razansky, Chem. Soc. Rev., 2024, 53, 6068 DOI: 10.1039/D3CS00565H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements