Issue 1, 2024

Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

Abstract

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. ‘Active’ nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy.

Graphical abstract: Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

Article information

Article type
Review Article
Submitted
01 Dec 2022
First published
30 Nov 2023

Chem. Soc. Rev., 2024,53, 204-226

Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

R. Goswami, A. Gupta, O. Bednova, G. Coulombe, D. Patel, V. M. Rotello and J. V. Leyton, Chem. Soc. Rev., 2024, 53, 204 DOI: 10.1039/D1CS00269D

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