Enantioselective enrichment of chiral 1-phenylethanol in the camphor-based chiral metal–organic framework CFA-22

Abstract

Enantioselective enrichment of R- or S-1-phenylethanol from racemic mixtures, reaching up to 42% enantiomeric excess and >60 wt% loading in the chiral CFA-22 (Coordination Framework Augsburg-22) metal–organic framework prepared from novel, scalable, and readily available camphor-based ligands, is demonstrated through single-crystal X-ray studies in conjunction with chiral high-performance liquid chromatography.