Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure

Abstract

The retention of the covalent binding of an organometalllic rhenium complex as a model for a technetium-99m imaging agent, to a protein at physiological body temperature 37 °C is described. Detailed structure comparisons are made to the related 100 K crystal structure. The generality of the need for this sort of analytical procedure for guiding ligand lead compound discovery is emphasised.

Graphical abstract: Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure

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Article information

Article type
Communication
Submitted
20 Aug 2024
Accepted
01 Oct 2024
First published
09 Oct 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024, Advance Article

Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure

F. J. F. Jacobs, J. R. Helliwell and A. Brink, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC04245J

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