Issue 76, 2024
From the journal:

Chemical Communications

A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP†

Valentyn Pozhydaiev,a   Daniella Al-Othman,a   Joseph Moran ORCID logo *abc  and  David Lebœuf ORCID logo *a  

* Corresponding authors

a Institut de Science et d’Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 67000 Strasbourg, France
E-mail: moran@unistra.fr, dleboeuf@unistra.fr

b Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada

c Institut Universitaire de France (IUF), 75005 Paris, France

Abstract

Here, we report the synthesis of tetrahydroquinolines between newly developed N-benzylhydroxylamine reagents and alkenes using HFIP as a solvent. This transformation is notably applicable to highly electronically deactivated styrenes and aliphatic alkenes, expanding the range of tetrahydroquinolines attainable.

Graphical abstract: A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D4CC04014G
Article type
Communication
Submitted
07 Aug 2024
Accepted
02 Sep 2024
First published
02 Sep 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 10504-10507

Permissions

Request permissions

A povarov-type reaction to access tetrahydroquinolines from N-benzylhydroxylamines and alkenes in HFIP

V. Pozhydaiev, D. Al-Othman, J. Moran and D. Lebœuf, Chem. Commun., 2024, 60, 10504 DOI: 10.1039/D4CC04014G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements