Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions

Abstract

Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. Here, fluorogenic tools for measuring CES1 activity are developed and demonstrated to report on these factors in living cells. These tools enable experiments that will develop a deeper understanding of CES1 metabolism.

Graphical abstract: Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions

Supplementary files

Article information

Article type
Communication
Submitted
19 Jul 2024
Accepted
06 Sep 2024
First published
09 Sep 2024

Chem. Commun., 2024, Advance Article

Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions

C. J. Karns, T. P. Spidle, E. Adusah, M. Gao, J. E. Nehls and M. W. Beck, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC03632H

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