Radiopharmaceutical-activated silicon naphthalocyanine nanoparticles towards tumor photodynamic therapy

Tingting Wang; Jingchao Li; Xun Zhang; Chengao Li; Jiang Ming; Jian Li; Dongsheng Zhang; Jun Yang; Nian Liu; Xinhui Su

doi:10.1039/D4CC03281K

Radiopharmaceutical-activated silicon naphthalocyanine nanoparticles towards tumor photodynamic therapy†

Tingting Wang,‡^a Jingchao Li,‡^b Xun Zhang,^a Chengao Li,^c Jiang Ming,

^d Jian Li,^a Dongsheng Zhang,^a Jun Yang,^a Nian Liu

*^a and Xinhui Su*^a

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* Corresponding authors

^a Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
E-mail: liuniancheer@gmail.com, suxinhui@zju.edu.cn

^b Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China

^c State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, China

^d Department of Chemistry, Xiamen University, Xiamen 361005, China

Abstract

Naphthalocyanine-based agents exhibit huge potential in photodynamic therapy, yet their photodynamic performance is restricted by the penetration depth of the external laser. Herein, we employed ¹⁸F-FDG as an internal light source to excite silicon naphthalocyanine nanoparticles to simultaneously circumvent radiative transition and boost ¹O₂ generation for tumor suppression.

Chemical Communications

Radiopharmaceutical-activated silicon naphthalocyanine nanoparticles towards tumor photodynamic therapy†

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