Issue 64, 2024

A NIR-II absorbing conjugated polymer based on tetra-fused isoindigo with ultrahigh photothermal conversion efficiency for cancer therapy

Abstract

A conjugated polymer, P4TTD-DPP, based on tetra-fused isoindigo-alt-diketopyrrolopyrrole, has been synthesized as a photothermal therapeutic nanotransducer within the near-infrared-II (NIR-II) window. P4TTD-DPP exhibits a notable mass extinction coefficient of 62.8 L g−1 cm−1 at 1064 nm. Additionally, P4TTD-DPP nanoparticles demonstrate remarkable photothermal conversion efficiency of 91.5% at 1064 nm and exhibit excellent anticancer efficacy under photothermal conditions.

Graphical abstract: A NIR-II absorbing conjugated polymer based on tetra-fused isoindigo with ultrahigh photothermal conversion efficiency for cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
25 May 2024
Accepted
15 Jul 2024
First published
15 Jul 2024

Chem. Commun., 2024,60, 8427-8430

A NIR-II absorbing conjugated polymer based on tetra-fused isoindigo with ultrahigh photothermal conversion efficiency for cancer therapy

J. Wu, M. Rao, Y. Zhu, P. Wang, M. Chen, Y. Qu, X. Zheng and Y. Jiang, Chem. Commun., 2024, 60, 8427 DOI: 10.1039/D4CC02546F

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