Issue 73, 2024

HFIP promoted carbo-lactonisation as a new route to functionalised lactones

Abstract

We have been able to induce a series of lactonisation reactions of unsaturated acids using a carbocationic intermediate formed in situ. The transformation generates five and six membered lactone rings AND forms a new exocyclic C–C bond at the same time, thus removing the need for further derivatisation of typical lactonisation products (such as from iodo lactonisation). The reaction is operationally straightforward, does not employ any metals and utilises readily accessible alcohol and unsaturated acid substrates.

Graphical abstract: HFIP promoted carbo-lactonisation as a new route to functionalised lactones

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2024
Accepted
14 Aug 2024
First published
15 Aug 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 9997-10000

HFIP promoted carbo-lactonisation as a new route to functionalised lactones

D. Aynetdinova, M. Jaschinski, T. C. Jenkins and T. J. Donohoe, Chem. Commun., 2024, 60, 9997 DOI: 10.1039/D4CC02472A

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