Issue 60, 2024

Synthesis of 1,2,4,5-tetra-substituted benzenes via copper-catalyzed dimerization of γ,δ-unsaturated ketones

Abstract

An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes via copper catalyzed dimerization of γ,δ-unsaturated ketones has been described. This one-pot procedure employs the γ,δ-unsaturated ketones as the sole substrate with multiple C–C bond formation. This protocol features broad substrate scope and provides a facile and robust method to construct polysubstituted benzene derivatives under mild conditions.

Graphical abstract: Synthesis of 1,2,4,5-tetra-substituted benzenes via copper-catalyzed dimerization of γ,δ-unsaturated ketones

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2024
Accepted
24 Jun 2024
First published
25 Jun 2024

Chem. Commun., 2024,60, 7753-7756

Synthesis of 1,2,4,5-tetra-substituted benzenes via copper-catalyzed dimerization of γ,δ-unsaturated ketones

K. Ma, C. Hong, J. Yan, Q. Li and T. Liu, Chem. Commun., 2024, 60, 7753 DOI: 10.1039/D4CC02458C

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