Constructing new bonds to carbon in dihydroquinazolines via hypervalent iodine(iii)-mediated C(sp3)–C(sp3) bond functionalization

Abstract

A hypervalent iodine(III)-mediated C(sp³)–C(sp³) bond functionalization reaction for the formation of C–C, C–P, and C–H bonds in dihydroquinazolines has been developed. This one-pot method involves successive oxidation of dihydroquinazoline substrates, mesolytic cleavage of a tert-butyl substituent, and bond formation to a variety of nucleophiles in moderate to high yields.