Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles

Naroa Sadaba; Jorge Leganés Bayón; Alshakim Nelson; Nicole F. Steinmetz

doi:10.1039/D4CC02411G

Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles†

Naroa Sadaba,‡^a Jorge Leganés Bayón,

‡^bcd Alshakim Nelson

*^a and Nicole F. Steinmetz

*^bcdefgh

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Washington, Seattle, WA 98195, USA
E-mail: alshakim@uw.edu

^b Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA
E-mail: nsteinmetz@ucsd.edu

^c Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

^d Department of Radiology, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

^e Center for Nano-ImmunoEngineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

^f Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

^g Center for Engineering in Cancer, Institute of Engineering in Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

^h Moores Cancer Center, University of California, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA

Abstract

In this work, we introduce a 3D-printable virus-like particle (VLP)-enhanced cross-linked biopolymer system. VLPs displaying surface-available acrylate groups were prepared through aza-Michael addition to serve as resins. The VLP resins were then photopolymerized into a poly(ethylene glycol) diacrylate (PEGDA) network following DLP 3D printing. This approach represents a convergence of disciplines, where the synergistic interaction between virology and additive manufacturing unlocks new frontiers in biotechnology.

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DOI: https://doi.org/10.1039/D4CC02411G
Article type: Communication
Submitted: 17 May 2024
Accepted: 11 Jul 2024
First published: 22 Jul 2024

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Chem. Commun., 2024,60, 9733-9736

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Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles

N. Sadaba, J. L. Bayón, A. Nelson and N. F. Steinmetz, Chem. Commun., 2024, 60, 9733 DOI: 10.1039/D4CC02411G

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Chemical Communications

Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles†

Abstract

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Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles

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