This paper shows a novel oxidative functionalization of α-amino ketones to yield the corresponding α-ketoamides and α-acylimidates. The reaction proceeds via oxygen delivery from water/alcohols in conjunction with an electron acceptor and 4-dimethylaminopyridine (DMAP). Mechanistic study indicates that DMAP exhibits a dual function of nucleophilic catalysis and proton abstraction.
Y. Wang, X. Liu, J. Zheng, J. Su, Q. Li, X. Cai, Q. Wang and X. Liang, Chem. Commun., 2024, 60, 7359 DOI: 10.1039/D4CC02348J
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