Issue 55, 2024

Simple electrochemical synthesis of cyclic hydroxamic acids by reduction of nitroarenes

Abstract

The electrochemical reduction of nitroarenes allows direct access to manifold nitrogen containing heterocycles. This work reports the simple and direct electro-organic synthesis of 18 different examples of 2H,4H-4-hydroxy-1,4-benzoxazin-3-ones in up to 81% yield. The scalability of the method was demonstrated on a gram-scale.

Graphical abstract: Simple electrochemical synthesis of cyclic hydroxamic acids by reduction of nitroarenes

Supplementary files

Article information

Article type
Communication
Submitted
01 May 2024
Accepted
13 Jun 2024
First published
14 Jun 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 7065-7068

Simple electrochemical synthesis of cyclic hydroxamic acids by reduction of nitroarenes

J. Winter, S. Lühr, K. Hochadel, M. D. J. Gálvez-Vázquez, T. Prenzel, D. Schollmeyer and S. R. Waldvogel, Chem. Commun., 2024, 60, 7065 DOI: 10.1039/D4CC02118E

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