A methodology is described herein for the synthesis of 2-aryl acetaldehydes from aryl aldehydes using TMSCHN2 under Au(I) catalysis. A diazoorgano Au(I) complex was shown to be an intermediate that reacts with ArCHO to give ArCH2CHO products. This homologation protocol was used to synthesize a wide range of 2-aryl acetaldehydes with high functional group compatibility.
A. ‘. Bakhoda, Chem. Commun., 2024, 60, 6937 DOI: 10.1039/D4CC01809E
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