Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals†‡
Tamal
Roy, 
§a
Eduard
Pogorilyy,
§a
Chubina P.
Kumarananthan,
b
Unni A.
Kvitastein,
b
Marco
Foscato,
a
Karl W.
Törnroos,
a
Tom C. H.
Adamsen
*ab
and
Erwan
Le Roux
*a
§a
Eduard
Pogorilyy,
§a
Chubina P.
Kumarananthan,
b
Unni A.
Kvitastein,
b
Marco
Foscato,
a
Karl W.
Törnroos,
a
Tom C. H.
Adamsen
*ab
and
Erwan
Le Roux
*a
Abstract
We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid–liquid extraction method, leads to a high radiochemical conversion up to 98%.
![Graphical abstract: Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D4CC01800A&imageInfo.ImageIdentifier.Year=2024)
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