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We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid–liquid extraction method, leads to a high radiochemical conversion up to 98%.

Graphical abstract: Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals

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