Issue 53, 2024

Amplification-free detection of Escherichia coli using an acidic deoxyribozyme-based paper device

Abstract

We reported a colorimetric paper-based device by integrating the modified acid RNA-cleaving DNAzymes (MaRCD-EC1) for highly sensitive (detection limit = 102 CFU mL−1), and rapid (within 30 min) detection of E. coli without amplification. This device exhibited a clinical sensitivity of 100% and a specificity of 100% in identifying E. coli-associated urinary tract infections (UTIs) using the clinical urine samples.

Graphical abstract: Amplification-free detection of Escherichia coli using an acidic deoxyribozyme-based paper device

Supplementary files

Article information

Article type
Communication
Submitted
13 Mar 2024
Accepted
20 May 2024
First published
22 May 2024

Chem. Commun., 2024,60, 6741-6744

Amplification-free detection of Escherichia coli using an acidic deoxyribozyme-based paper device

G. Zhang, Y. Wu, W. Xue, D. Wang, Y. Chang and M. Liu, Chem. Commun., 2024, 60, 6741 DOI: 10.1039/D4CC01150C

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