Issue 51, 2024
From the journal:

Chemical Communications

Manganese(ii) promotes prebiotically plausible non-enzymatic RNA ligation reactions†

Ziwei Liu, ORCID logo *ab   Clancy Zhijian Jiang,b   Andrew D. Bond, ORCID logo c   Nicholas J. Toscab  and  John D. Sutherlanda  

* Corresponding authors

a MRC–Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK

b Department of Earth Sciences, University of Cambridge, Downing Street, UK
E-mail: zwl25@cam.ac.uk

c Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, UK

Abstract

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5′-AMP as an analogue.

Graphical abstract: Manganese(ii) promotes prebiotically plausible non-enzymatic RNA ligation reactions

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Article information

DOI
https://doi.org/10.1039/D4CC01086H
Article type
Communication
Submitted
07 Mar 2024
Accepted
29 May 2024
First published
30 May 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 6528-6531

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Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions

Z. Liu, C. Z. Jiang, A. D. Bond, N. J. Tosca and J. D. Sutherland, Chem. Commun., 2024, 60, 6528 DOI: 10.1039/D4CC01086H

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