Issue 47, 2024

Oxalic acid as a dual C1 surrogate for heterogeneous palladium-catalyzed tandem four-component quinazolinone synthesis

Abstract

Herein, a heterogeneous Pd/C-catalyzed direct one-step four-component double carbonylative approach for cascade synthesis of 2-aryl quinazolinones has been reported for the first time starting from 2-iodoaniline derivatives and aryl iodides. The given reaction involves the simultaneous implementation of two different gaseous surrogates i.e., ammonium carbamate as an NH3 precursor and oxalic acid as a bi-functional reagent acting as a CO as well as a C-atom surrogate under ligand-free conditions.

Graphical abstract: Oxalic acid as a dual C1 surrogate for heterogeneous palladium-catalyzed tandem four-component quinazolinone synthesis

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2024
Accepted
30 Apr 2024
First published
01 May 2024

Chem. Commun., 2024,60, 6043-6046

Oxalic acid as a dual C1 surrogate for heterogeneous palladium-catalyzed tandem four-component quinazolinone synthesis

Sheetal, P. Sharma, A. Kumar, N. Sharma, K. Giri and P. Das, Chem. Commun., 2024, 60, 6043 DOI: 10.1039/D4CC01084A

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