Issue 41, 2024

Iridium(iii)-catalyzed photoredox cross-coupling of alkyl bromides with trialkyl amines: access to α-alkylated aldehydes

Abstract

A C(sp3)–C(sp3) cross coupling approach based on an iridium-photocatalytic radical process has been developed enabling the synthesis of various α-alkylated aldehydes from easily available/synthesized alkyl bromides and trialkyl amines under mild photocatalytic conditions. The synthesized aldehydes are also explored as a functional handle for various useful products such as carboxylic acid, alcohol and N-heterocycle synthesis.

Graphical abstract: Iridium(iii)-catalyzed photoredox cross-coupling of alkyl bromides with trialkyl amines: access to α-alkylated aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2024
Accepted
22 Apr 2024
First published
23 Apr 2024

Chem. Commun., 2024,60, 5435-5438

Iridium(III)-catalyzed photoredox cross-coupling of alkyl bromides with trialkyl amines: access to α-alkylated aldehydes

G. Shukla, M. Singh, S. Singh and M. S. Singh, Chem. Commun., 2024, 60, 5435 DOI: 10.1039/D4CC01043D

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