Fluorescence monitoring of refluxed tyrosinase using endoplasmic reticulum-localized enzymatic activity-based sensing

Dunji Shu; Wenzhi Xie; Huihong Liu; Jingjing Li; Jinglong Jiao; Guojiang Mao; Sheng Yang; Kai Zhang

doi:10.1039/D4CC00662C

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Fluorescence monitoring of refluxed tyrosinase using endoplasmic reticulum-localized enzymatic activity-based sensing†

Dunji Shu,‡^a Wenzhi Xie,‡^c Huihong Liu,‡^ac Jingjing Li,^a Jinglong Jiao,^a Guojiang Mao,^d Sheng Yang

*^a and Kai Zhang*^b

Author affiliations

* Corresponding authors

^a Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China
E-mail: yangsheng@hunnu.edu.cn

^b Department of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, P. R. China
E-mail: kzhang@swmu.edu.cn

^c Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China

^d Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, P. R. China

Abstract

A tyrosinase-activatable fluorescent probe with endoplasmic reticulum targetability was developed for the first time. It can ratiometrically fluoresce and hence be used to monitor refluxed tyrosinase into the endoplasmic reticulum.

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Article information

DOI: https://doi.org/10.1039/D4CC00662C
Article type: Communication
Submitted: 08 Feb 2024
Accepted: 17 Apr 2024
First published: 18 Apr 2024

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Chem. Commun., 2024,60, 5618-5621

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Fluorescence monitoring of refluxed tyrosinase using endoplasmic reticulum-localized enzymatic activity-based sensing

D. Shu, W. Xie, H. Liu, J. Li, J. Jiao, G. Mao, S. Yang and K. Zhang, Chem. Commun., 2024, 60, 5618 DOI: 10.1039/D4CC00662C

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Chemical Communications

Fluorescence monitoring of refluxed tyrosinase using endoplasmic reticulum-localized enzymatic activity-based sensing†

Abstract

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Fluorescence monitoring of refluxed tyrosinase using endoplasmic reticulum-localized enzymatic activity-based sensing

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