Palladium-catalyzed enantioselective arylation of trichloro- or tri-/difluoroacetaldimine precursors

Abstract

A palladium-catalyzed asymmetric α-arylation of N-carbamoyl imine precursors containing CCl₃, CF₃ and CF₂H is presented. This protocol provides facile access to a series of chiral α-aryl trichloroethylamines bearing various functional groups, with moderate to high yields (40–82% yield) and high enantioselectivity (80–99% ee).