A novel and interesting controllable spirocyclization of unsaturated barbiturates with enamino esters for the assembly of cyclopentenyl and pyrrolinyl spirobarbiturates has been developed under ball-milling conditions. The present protocol features high chemoselectivity and efficiency, excellent functional group tolerance and mild reaction conditions.
M. Li, M. Lu, P. Xu, S. Chen, L. Wu, Z. Zhang and H. Xu, Chem. Commun., 2024, 60, 3958 DOI: 10.1039/D3CC06327E
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