Modular synthesis of congested β2,2-amino acids via the merger of photocatalysis and oxidative functionalisations

Abstract

A two-step protocol for the modular synthesis of β²- and α-quaternary β^2,2-amino acid derivatives is reported. The key steps are a photocatalytic hydroalkylation reaction, followed by an oxidative functionalisation to access N-protected β-amino acids, esters, and amides. This strategy can be effectively scaled up via continuous-flow technology.