A smart cysteine-activated and heavy-atom-free nano-photosensitizer for photodynamic therapy to treat cancers

Shengze Su; Xingcan Li; Qian An; Tao Liang; Yanying Wang; Hongping Deng; Xiaoxing Xiong; Wing-Leung Wong; Huijuan Zhang; Chunya Li

doi:10.1039/D3CC06019E

A smart cysteine-activated and heavy-atom-free nano-photosensitizer for photodynamic therapy to treat cancers†

Shengze Su,^a Xingcan Li,^a Qian An,^a Tao Liang,^d Yanying Wang,^a Hongping Deng,^c Xiaoxing Xiong,^c Wing-Leung Wong,

*^b Huijuan Zhang*^a and Chunya Li

*^ac

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* Corresponding authors

^a Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science & Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, South-Central Minzu University, Wuhan 430074, China

^b State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China

^c Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China

^d Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China

Abstract

A smart and heavy-atom-free photoinactive nano-photosensitizer capable of being activated by cysteine at the tumor site to generate highly photoactive nano-photosensitizers that show strong NIR absorption and fluorescence with a good singlet oxygen quantum yield (16.8%) for photodynamic therapy is reported.

Chemical Communications

A smart cysteine-activated and heavy-atom-free nano-photosensitizer for photodynamic therapy to treat cancers†

Abstract

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A smart cysteine-activated and heavy-atom-free nano-photosensitizer for photodynamic therapy to treat cancers

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