Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

Adél Szerlauth; Tamara Madácsy; Gergely Ferenc Samu; Péter Bíró; Miklós Erdélyi; Gábor Varga; Zhi Ping Xu; József Maléth; István Szilágyi

doi:10.1039/D3CC05762C

Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide†

Adél Szerlauth,

^a Tamara Madácsy,^b Gergely Ferenc Samu,

^c Péter Bíró,

^d Miklós Erdélyi,^d Gábor Varga,

^e Zhi Ping Xu,^f József Maléth^b and István Szilágyi

*^a

Author affiliations

* Corresponding authors

^a MTA-SZTE Momentum Biocolloids Research Group, Interdisciplinary Excellence Center, University of Szeged, H-6720 Szeged, Hungary
E-mail: szistvan@chem.u-szeged.hu

^b MTA-SZTE Momentum Epithelial Cell Signaling and Secretion Research Group, Interdisciplinary Excellence Center, University of Szeged, H-6720 Szeged, Hungary

^c Department of Molecular and Analytical Chemistry, University of Szeged, H-6720 Szeged, Hungary

^d Department of Optics and Quantum Electronics, University of Szeged, H-6720 Szeged, Hungary

^e Department of Applied and Environmental Chemistry, University of Szeged, H-6720 Szeged, Hungary

^f Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD-4072 Brisbane, Australia

Abstract

Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase- and catalase-like activities in chemical assays, while proving as efficient antioxidants in the reduction of intracellular oxidative stress. The results indicate the great promise of CMA in antioxidant therapies.

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Article information

DOI: https://doi.org/10.1039/D3CC05762C
Article type: Communication
Submitted: 24 Nov 2023
Accepted: 02 Jan 2024
First published: 02 Jan 2024
This article is Open Access

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Chem. Commun., 2024,60, 1325-1328

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Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

A. Szerlauth, T. Madácsy, G. F. Samu, P. Bíró, M. Erdélyi, G. Varga, Z. P. Xu, J. Maléth and I. Szilágyi, Chem. Commun., 2024, 60, 1325 DOI: 10.1039/D3CC05762C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide†

Abstract

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Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

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