Transition metal-catalyzed asymmetric nitrene transfer is a powerful method to generate enantioenriched amines found in natural products and bioactive molecules. A highly chemo- and enantioselective intramolecular silver-catalysed aziridination of 2,2,2-trichloroethoxysulfonyl (Tces)-protected carbamimidates gives [4.1.0]-bicyclic aziridines in good yields and up to 99% ee.
T. A. Trinh, Y. Fu, D. B. Hu, S. A. Zappia, I. A. Guzei, P. Liu and J. M. Schomaker, Chem. Commun., 2024, 60, 224 DOI: 10.1039/D3CC05670H
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